Mode of Action of Glucocorticoids

Mode of Action of Glucocorticoids. I. Stimulation of Gluconeogenesis Independent of Synthesis De Novo of Enzymes.

The adrenal glucocorticoids regulate carbohydrate formation and protein synthesis (l-6), but the mechanism by which they influence either of these processes remains to be elucidated. The administration of glucocorticoids to rats is followed by increased formation of several liver enzymes that participate in amino acid degradation or gluconeogenesis; e.g. tyrosineol-ketoglutarate transaminase (7...

Mode of Action of Glucocorticoids I. STIMULATION OF GLUCONEOGENESIS INDEPENDENT OF SYXTHESIS DE NOVO OF ENZYMES*

The adrenal glucocorticoids regulate carbohydrate formation and protein synthesis (l-6), but the mechanism by which they influence either of these processes remains to be elucidated. The administration of glucocorticoids to rats is followed by increased formation of several liver enzymes that participate in amino acid degradation or gluconeogenesis; e.g. tyrosineol-ketoglutarate transaminase (7...

Liposomal encapsulation of glucocorticoids alters their mode of action in the treatment of experimental autoimmune encephalomyelitis.

Glucocorticoids (GCs) are widely used to treat acute relapses of multiple sclerosis (MS). In this study, we demonstrate that liposomal encapsulation augments the therapeutic potency of GCs as they ameliorate experimental autoimmune encephalomyelitis (EAE) to the same extent as free GC, but at strongly reduced dosage and application frequency. Importantly, this is accompanied by an altered mode ...

evolution and mode of action of pulsed radiofrequency

Mode of Action

Being impermeable to folic acid, many bacteria must rely on their ability to synthesise folate from PABA, Pteridine, and glutamate in contrast the mammalian in cells cannot synthesise folic acid and must obtain preformed folate as a vitamin in their diet. The sulphonamides are structurally similar to PABA, the sulphonamides competitively inhibit dihydropteroate synthetase, the enzyme that catal...